Akkermansia muciniphila (AKK) supplier specification
Nutrition BioTech is a bulk Akkermansia muciniphila (AKK) ingredient supplier and manufacturer, supplying strain DSM 35743 as live biomass, pasteurized / heat-inactivated cells or postbiotic powder with potency stated per gram on the Certificate of Analysis, for B2B microbiome and gut-health formulation.
Akkermansia muciniphila is a whole-cell microbial ingredient, so it has no CAS number, no molecular formula and no molecular weight; identity runs through species and strain designation instead. The first specification questions are therefore format (live, pasteurized, inactivated or postbiotic), potency unit, strain designation, storage requirement and dosage format — those five determine everything downstream.
| Ingredient name | Akkermansia muciniphila (AKK) |
|---|---|
| Synonyms | AKK; Akkermansia; mucin-degrading gut commensal; next-generation microbiome ingredient |
| Taxonomy | Bacteria → Verrucomicrobiota → Akkermansiaceae → Akkermansia muciniphila |
| Strain designation | DSM 35743 — the strain designation carried on our specification sheet. The deposit certificate is available under buyer review. Species identity is confirmed by sequencing and reported on the Certificate of Analysis. |
| CAS number | Not applicable — whole-cell biological ingredient, identified by species and strain designation rather than by CAS number |
| Material formats | Live biomass, pasteurized / heat-inactivated cells, or postbiotic powder. The exact format is confirmed per order and stated on the specification sheet. |
| Identity & potency | Strain designation and potency unit are stated on the Certificate of Analysis — CFU per gram for live material, or total cells / AFU per gram for pasteurized and inactivated material. Potency is not interchangeable between formats. |
| Production route | Anaerobic fermentation followed by harvest and stabilization (freeze-drying or spray-drying). Carrier, cryoprotectant and any pasteurization step are stated on the specification sheet. |
| Appearance | Off-white to light beige powder; shade depends on carrier and drying route |
| Storage & stability | Per specification sheet. Live formats require cold-chain handling; pasteurized and postbiotic formats are more tolerant of ambient logistics. Stability data provided on request. |
| Typical applications | Capsules, sachets and stick packs, dual-chamber and moisture-controlled formats, and blends alongside fiber, protein and polyphenol systems for B2B manufacturing |
| Documentation | Download public specification sheet Public sheet prepared from the current product-page specification block; not a batch-specific Certificate of Analysis. Lot-specific COA and supporting records are available for qualified buyer review when appropriate. |
| Regulatory note | Regulatory status for live, pasteurized and postbiotic microbial ingredients is strain-specific and differs by market and by format. In the EU, Commission Implementing Regulation (EU) 2022/168 authorises pasteurised Akkermansia muciniphila strain MucT (ATCC BAA-835 / CIP 107961) as a novel food; other strains are not covered by that authorisation. In the United States, market access for a given strain runs through New Dietary Ingredient notification or GRAS, which are likewise strain-specific. Buyers are responsible for confirming the status of the supplied strain and format for their destination market before formulation. |
| Quality system | ISO 22000:2018, FSSC 22000, HACCP and GMP (certificates provided on request) |
| Supplier | Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States |
AKK / Akkermansia Muciniphila for gut-aging and post-GLP-1 microbiome products.
A next-generation microbiome ingredient route for brands building gut barrier, metabolic resilience, fullness-after-meals, and post-GLP-1 companion concepts with a serious COA/spec/sample review path.
Postbiotic / inactive route review
Gut-aging axis
COA + spec review
Product first: verify the AKK material
Before building the platform story, confirm the exact material: live, pasteurized, inactive, or postbiotic status; potency unit; strain/source identity; COA/spec; storage; and target dosage form.
Why brands care now
Probiotic shelves are crowded. AKK gives product teams a more ownable gut-aging and metabolic-routine route for capsules, powders, stick packs, and post-GLP-1 companion concepts.
Best-fit buyer
Supplement brands, R&D teams, formulators, distributors, and contract manufacturers building next-generation gut health, weight-maintenance routine, and microbiome-forward longevity products.
COA-backed material proof
Inactive AKK powder with total-cell-count and quality-panel review.
Reviewed COAs identify Akkermansia muciniphila inactivated bacteria powder, including AM06 batches, with total cell count specification NLT 2.0 x 10^11 cells/g and batch results around 2.4-2.9 x 10^11 cells/g. Viable cell result is listed as absent, ND, or not detected, with moisture, heavy metals, microbial limits, storage, and shelf-life review available for qualified projects.
Patent, clinical, and source-origin claims should be reviewed from separate source files before public use.
Post-GLP-1 companion route
AKK can be reviewed with fiber, protein, creatine, berberine, DHB, and polyphenol systems for gut, metabolic-routine, and muscle-support product concepts.
Buyer file package
The useful next step is a material review, not a generic sample request. Ask for the files that match your formula and market route.
Claim boundary
Public language should stay in gut-aging, microbiome, wellness, structure/function, formulation, and quality-review territory. Stronger technical discussion belongs in buyer-specific file review.
Published category signal
Published human and regulatory work has helped make live and pasteurized Akkermansia muciniphila a serious next-generation microbiome category. Product-specific claims still require exact material and evidence review.
Format review
Capsules are the cleanest starting route. Powders, sachets, blends, gummies, and stick packs require review of heat, moisture, potency unit, taste, storage, and label strategy.
Do not make it generic
AKK should not read like another commodity probiotic. The commercial story is gut-aging plus post-GLP-1 routine plus a serious COA/spec route.
Regulatory status of Akkermansia muciniphila
The entries below summarise publicly available regulatory documents and are provided as context for buyers. They are not claims about Nutrition BioTech material, and no health outcome is claimed or implied for any finished product. Authorisation is specific to the source, form and conditions of use described in each instrument. Buyers are responsible for confirming the status of the ingredient in their own market and for the claims they make on their own labels. Last reviewed: 3 August 2026.
EU authorisation covers a specific strain in pasteurised form
Commission Implementing Regulation (EU) 2022/168 of 8 February 2022 authorises the placing on the market of pasteurised Akkermansia muciniphila as a novel food. The authorisation is specific to the pasteurised form of strain MucT (ATCC BAA-835 / CIP 107961) under the conditions of use set out in the Regulation. Other strains and live forms are not covered by that authorisation.
Commission Implementing Regulation (EU) 2022/168, 8 February 2022 — source
EFSA safety assessment underlying the EU authorisation
The EU authorisation followed a safety assessment by the EFSA Panel on Nutrition, Novel Foods and Food Allergens, which evaluated pasteurised Akkermansia muciniphila as a novel food under Regulation (EU) 2015/2283.
EFSA Journal, 2021. DOI 10.2903/j.efsa.2021.6780 — source
United States: notification is strain-specific
In the United States a bacterial ingredient of this type is handled through the new dietary ingredient notification route under 21 U.S.C. § 350b, which is specific to the notified strain, form and conditions of use. NDI notification 1363 covers pasteurised Akkermansia muciniphila strain HB05P. A notification covering one strain does not extend to a different strain.
FDA New Dietary Ingredient Notification process; NDIN 1363 — source
Specification FAQ
Does Akkermansia muciniphila have a CAS number?
Not applicable — whole-cell biological ingredient, identified by species and strain designation rather than by CAS number
Which Akkermansia muciniphila strain does Nutrition BioTech supply?
DSM 35743 — the strain designation carried on our specification sheet. The deposit certificate is available under buyer review. Species identity is confirmed by sequencing and reported on the Certificate of Analysis.
What formats is Akkermansia muciniphila available in?
Live biomass, pasteurized / heat-inactivated cells, or postbiotic powder. The exact format is confirmed per order and stated on the specification sheet.
How is Akkermansia muciniphila identity and potency confirmed?
Strain designation and potency unit are stated on the Certificate of Analysis — CFU per gram for live material, or total cells / AFU per gram for pasteurized and inactivated material. Potency is not interchangeable between formats.
Is Akkermansia muciniphila authorised for use in the EU?
Regulatory status for live, pasteurized and postbiotic microbial ingredients is strain-specific and differs by market and by format. In the EU, Commission Implementing Regulation (EU) 2022/168 authorises pasteurised Akkermansia muciniphila strain MucT (ATCC BAA-835 / CIP 107961) as a novel food; other strains are not covered by that authorisation. In the United States, market access for a given strain runs through New Dietary Ingredient notification or GRAS, which are likewise strain-specific. Buyers are responsible for confirming the status of the supplied strain and format for their destination market before formulation.
How should Akkermansia muciniphila be stored?
Per specification sheet. Live formats require cold-chain handling; pasteurized and postbiotic formats are more tolerant of ambient logistics. Stability data provided on request.
Published research context
Akkermansia muciniphila has a substantial peer-reviewed literature. The entries below are restricted to identity, taxonomy, cultivation and stabilisation — the axes that bear on specifying and handling the raw material. Several concern the species in general or the type strain MucT (ATCC BAA-835) and are not studies of the strain supplied here; Akkermansia properties are strain-specific and findings should not be transferred between strains or between live, pasteurised and postbiotic formats. The studies below are provided as technical context for formulators evaluating this raw material. These entries summarise what the cited publications report. They are not claims about Nutrition BioTech material, and no health, therapeutic or cosmetic outcome is claimed or implied for any finished product. Buyers are responsible for the claims they make on their own labels and for confirming what is permitted in their market.
- Original species description and type strainReported the isolation of strain MucT by dilution to extinction of human faeces in anaerobic medium containing gastric mucin as sole carbon and nitrogen source, describing a Gram-negative, strictly anaerobic, non-motile, non-spore-forming oval-shaped bacterium in subdivision 1 of the Verrucomicrobia. This is the publication that proposed the name Akkermansia muciniphila gen. nov., sp. nov., with MucT (= ATCC BAA-835T = CIP 107961T) as type strain — the reference point against which any Akkermansia designation is compared.Derrien M, Vaughan EE, Plugge CM, de Vos WM. Int J Syst Evol Microbiol. 2004;54(Pt 5):1469-1476. PMID 15388697. DOI 10.1099/ijs.0.02873-0. source
- Genome-based reclassification: the genus is not one speciesApplied digital DNA-DNA hybridisation, average nucleotide identity and core-genome phylogeny to 104 whole-genome sequences and reclassified the strains into three clusters: cluster I comprising Akkermansia muciniphila (type strain ATCC BAA-835T), cluster II described as the new species Akkermansia massiliensis sp. nov. (type strain Marseille-P6666T = CSUR P6666 = CECT 30548), and cluster III proposed as Candidatus Akkermansia timonensis. Reported evidence that isolates labelled A. muciniphila are not necessarily that species, which is why species identity should rest on sequencing rather than on a supplier label.Ndongo S, Armstrong N, Raoult D, Fournier PE. Sci Rep. 2022;12(1):21747. PMID 36526682. DOI 10.1038/s41598-022-25873-0. source
- Genome stability across long-term subculturingGrew type strain MucT for over 1,000 generations under five culturing conditions and sequenced single-colony isolates. Reported no mutations detected in isolates grown in porcine gastric mucin media with or without shaking, and mutation rates between 2.1 × 10-10 and 8.6 × 10-11 per nucleotide per generation in minimal media containing high or low N-acetylglucosamine, or low N-acetylglucosamine with 1% ox bile.Ligthart K et al. Microbiol Spectr. 2026;14(4):e0240025. PMID 41805175. DOI 10.1128/spectrum.02400-25. source
- Defined minimal medium and the N-acetylglucosamine requirementDesigned a defined minimal medium from a genome-scale metabolic model and the composition of mucin. Reported that Akkermansia muciniphila does not encode GlmS, the enzyme mediating conversion of fructose-6-phosphate to glucosamine-6-phosphate, so N-acetylglucosamine must be present in the medium for growth — a fermentation-media constraint rather than a property of the finished ingredient.van der Ark KCH et al. Microb Biotechnol. 2018;11(3):476-485. PMID 29377524. DOI 10.1111/1751-7915.13033. source
- Lyophilization medium and post-drying viability of anaerobesDeveloped and optimised a broad-spectrum lyophilization medium of skim milk, cryoprotectants and antioxidants, evaluated across a panel that included Akkermansia muciniphila alongside Lactobacillus, Bifidobacterium, Bacteroides uniformis and Gordonibacter urolithinfaciens. Reported increased survival rates for all strains and particularly for oxygen-sensitive ones, no significant viability loss after six months of storage at 4 °C, retained cell membrane integrity by scanning electron microscopy and flow cytometry, and attenuated oxidative stress in anaerobes with ascorbic acid supplementation.Eshaghi Gorji M, Li W, Zhao D. Food Res Int. 2026;237:119412. PMID 42169360. DOI 10.1016/j.foodres.2026.119412. source
