Calcium alpha-ketoglutarate (Ca-AKG) 98% supplier specification
Nutrition BioTech is a bulk calcium alpha-ketoglutarate (Ca-AKG) ingredient supplier and manufacturer, supplying Ca-AKG monohydrate (CAS 71686-01-6) at 98% minimum as CalciAKG™, produced by synthesis and crystallisation, for B2B nutraceutical and longevity-category formulation.
Ca-AKG is a gram-scale calcium salt supplied as the monohydrate, so three numbers drive every formulation decision: the assay, the water content and the elemental calcium content, all of which come off the Certificate of Analysis. Label maths should be run on the monohydrate basis rather than the anhydrous basis.
| Ingredient name | Calcium alpha-ketoglutarate (Ca-AKG) 98%, monohydrate — CalciAKG™ |
|---|---|
| Synonyms | Ca-AKG; calcium AKG; calcium 2-oxoglutarate monohydrate; calcium 2-oxopentanedioate; alpha-ketoglutaric acid calcium salt |
| CAS number | 71686-01-6 — the CAS number carried on our specification sheet for the monohydrate |
| Machine-readable identifiers | InChIKey LADYPAWUSNPKJF-UHFFFAOYSA-L · PubChem CID 3018235 |
| Molecular formula | C5H4CaO5 · H2O (monohydrate) — C5H4CaO5 on the anhydrous basis |
| Molecular weight | 202.18 g/mol (monohydrate) · 184.16 g/mol (anhydrous basis) |
| Assay / purity | 98% minimum, stated on the Certificate of Analysis for each lot together with the assay method. |
| Hydration & calcium content | Supplied as the monohydrate. Water content and elemental calcium content are stated on the Certificate of Analysis and must be used for label calculations rather than assumed. |
| Production route | Organic synthesis: neutralisation of alpha-ketoglutaric acid with a calcium source, followed by crystallisation and drying. |
| Appearance | White to off-white crystalline powder |
| Solubility | Slightly soluble in water; insoluble in ethanol. |
| Typical applications | Capsules, tablets and powder blends for B2B nutraceutical manufacturing. Servings are gram-scale, so label space and tablet weight should be checked early. |
| Documentation | Download public specification sheet Public sheet prepared from the current product-page specification block; not a batch-specific Certificate of Analysis. Lot-specific COA and supporting records are available for qualified buyer review when appropriate. |
| Quality system | ISO 22000:2018, FSSC 22000, HACCP and GMP (certificates provided on request) |
| Supplier | Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States |
Ca-AKG 98% (CalciAKG™)
High-purity Ca-AKG for premium longevity and cellular resilience formulations.
Why brands ask for it
CalciAKG™ Ca-AKG 98% is designed for brands developing advanced healthy-aging products. It fits cellular resilience, epigenetic aging and longevity stacks where purity, documentation and capsule/tablet performance matter to B2B buyers.
Finished-product fit
Longevity stack, biological age, healthy aging, active longevity. The strongest conversations start with format, serving size, documentation, and how the material behaves in the intended formula.
What makes the sample useful
- 98% Ca-AKG purity story
- Calcium salt form for capsules/tablets
- Strong fit in premium longevity products
Before the sample ships
- Confirm active marker, assay method, and specification range.
- Confirm calcium content.
- Request contaminant, residual solvent, and microbiology files as needed.
- Match the material to the target capsule, tablet, sachet, gummy, or powder format.
- Confirm it suitable for longevity claims.
File Package
Ask for the material files that match your market, dosage form, and internal review process.
Available documents may include: COA / Specification / Allergen Statement / GMO Statement / Vegan Statement / Heavy Metals / Microbial Limits / Manufacturing Flow Chart / Residual Solvent / Country of Origin / Composition Statement.
Regulatory & Facility Support
Regulatory review notes for the target market can be provided. Nutrition BioTech does not hold and does not claim any GRAS notification or NDI notification for this material.
Facility and quality system support follows the same certificate set named in the specification table: ISO 22000:2018, FSSC 22000, HACCP and GMP. The holding entity for each certificate is named on the certificate and confirmed under buyer review.
Specification FAQ
What is the CAS number for Calcium alpha-ketoglutarate?
The CAS number for Calcium alpha-ketoglutarate is 71686-01-6 — the CAS number carried on our specification sheet for the monohydrate. The molecular formula is C5H4CaO5 · H2O (monohydrate) — C5H4CaO5 on the anhydrous basis and the molecular weight is 202.18 g/mol (monohydrate) · 184.16 g/mol (anhydrous basis). Machine-readable identifiers: InChIKey LADYPAWUSNPKJF-UHFFFAOYSA-L · PubChem CID 3018235.
What purity is Calcium alpha-ketoglutarate supplied at, and by which method?
98% minimum, stated on the Certificate of Analysis for each lot together with the assay method.
Is Calcium alpha-ketoglutarate soluble in water?
Slightly soluble in water; insoluble in ethanol.
Published research context
Calcium alpha-ketoglutarate and the alpha-ketoglutarate anion have a peer-reviewed literature covering absorption, solution chemistry and analytical methods. The studies below are provided as technical context for formulators evaluating this raw material. These entries summarise what the cited publications report. They are not claims about Nutrition BioTech material, and no health, therapeutic or cosmetic outcome is claimed or implied for any finished product. Buyers are responsible for the claims they make on their own labels and for confirming what is permitted in their market.
- Intestinal absorption and plasma kineticsAdministered alpha-ketoglutarate intravenously, intra-portally, orally and directly into the duodenum or ileum of catheterized pigs, and reported that alpha-ketoglutarate was absorbed significantly better from the upper small intestine than from distal sections, that low pH and Fe2+ ions enhanced gut absorption, and that alpha-ketoglutarate delivered to the portal vein was eliminated from blood with a half-life under 5 minutes, attributed to rapid metabolism in enterocytes and liver.Dabek M, Kruszewska D, Filip R, Hotowy A, et al. J Anim Physiol Anim Nutr (Berl). 2005;89(11-12):419-426. PMID 16401194. DOI 10.1111/j.1439-0396.2005.00566.x. source
- Non-enzymatic decarboxylation by peroxidesReported by HPLC, in a chemical system and in rat liver mitochondria, that alpha-ketoglutarate undergoes non-enzymatic decarboxylation in the presence of hydrogen peroxide or tert-butyl hydroperoxide, forming succinate. Compatibility with peroxides and other oxidizing agents is therefore a relevant consideration when handling or co-formulating this ingredient.Fedotcheva NI, Sokolov AP, Kondrashova MN. Free Radic Biol Med. 2006;41(1):56-64. PMID 16781453. DOI 10.1016/j.freeradbiomed.2006.02.012. source
- HPLC quantification after dansylhydrazine derivatizationDescribed a method for alpha-ketoglutaric acid using tandem solid-phase extraction on an ion-exchange cartridge, derivatization of the carbonyl group with dansylhydrazine catalyzed by trifluoroacetic acid, reversed-phase separation on a C8 column and UV plus fluorescence detection in a single gradient run, with good reproducibility and specificity. The matrix of this work is plasma, not raw-material assay; identity and content of supplied material follow the methods stated in our specification and COA.Donnarumma F, Wintersteiger R, Schober M, Greilberger J, et al. Anal Sci. 2013;29(12):1177-1182. PMID 24334984. DOI 10.2116/analsci.29.1177. source
