Apigenin 98% (Somnigenin™) supplier specification
Nutrition BioTech is a bulk apigenin ingredient supplier and manufacturer, supplying apigenin (CAS 520-36-5) at 98% minimum by HPLC as Somnigenin™, produced by botanical extraction and purification, for B2B nutraceutical formulation.
Apigenin is a low-dose, poorly water-soluble flavone, so the practical specification questions are particle size, wetting behaviour and blend uniformity as much as assay. Every lot ships with a Certificate of Analysis stating identity, HPLC assay and the assay basis.
| Ingredient name | Apigenin 98% — Somnigenin™ |
|---|---|
| Synonyms | Apigenin; 4′,5,7-trihydroxyflavone; chamomile flavone; apigenol |
| CAS number | 520-36-5 |
| Machine-readable identifiers | InChIKey KZNIFHPLKGYRTM-UHFFFAOYSA-N · PubChem CID 5280443 |
| Molecular formula | C15H10O5 |
| Molecular weight | 270.24 g/mol |
| Assay / purity | 98% minimum by HPLC, stated on the Certificate of Analysis for each lot. |
| Source / production route | Botanical extraction and purification (flavone naturally present in chamomile, parsley and celery). The plant source and solvent system for the supplied lot are stated on the specification sheet. |
| Appearance | Light yellow to yellow crystalline powder |
| Solubility | Practically insoluble in water; soluble in DMSO and in dilute alkali. Particle size and wetting behaviour should be confirmed for the intended dosage form. |
| Typical applications | Capsules, tablets and low-dose powder blends for B2B nutraceutical manufacturing; commonly formulated alongside magnesium, L-theanine and glycine |
| Documentation | Download public specification sheet Public sheet prepared from the current product-page specification block; not a batch-specific Certificate of Analysis. Lot-specific COA and supporting records are available for qualified buyer review when appropriate. |
| Quality system | ISO 22000:2018, FSSC 22000, HACCP and GMP (certificates provided on request) |
| Supplier | Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States |
Apigenin 98% (Somnigenin™)
High-purity apigenin for calm, sleep-support and nighttime longevity formulas.
Why brands ask for it
Somnigenin™ Apigenin 98% is designed for brands seeking a clean, non-melatonin nighttime ingredient with a strong flavonoid story. It fits sleep, stress-support, calm focus and longevity evening formulas where a precise low-dose active is preferred.
Finished-product fit
Sleep routine, relaxation, stress resilience, longevity night stack. The strongest conversations start with format, serving size, documentation, and how the material behaves in the intended formula.
What makes the sample useful
- High-purity 98% active
- Works in sleep stacks with magnesium, theanine, glycine
- Differentiated botanical flavonoid compared with melatonin
Before the sample ships
- Confirm source, identity, and supporting documentation.
- Confirm it 98%.
- Confirm particle size suitable.
- Request contaminant, residual solvent, and microbiology files as needed.
- Request allergen, GMO, vegan, and source statements.
File Package
Ask for the material files that match your market, dosage form, and internal review process.
Available documents may include: COA / Specification / Allergen Statement / GMO Statement / Vegan Statement / Heavy Metals / Microbial Limits / Manufacturing Flow Chart / Residual Solvent / Country of Origin / Composition Statement.
Regulatory & Facility Support
Regulatory review notes for the target market can be provided. Nutrition BioTech does not hold and does not claim any GRAS notification or NDI notification for this material.
Facility and quality system support follows the same certificate set named in the specification table: ISO 22000:2018, FSSC 22000, HACCP and GMP. The holding entity for each certificate is named on the certificate and confirmed under buyer review.
Published research context
Apigenin has an extensive peer-reviewed literature. The studies below are provided as technical context for formulators evaluating this raw material. These entries summarise what the cited publications report. They are not claims about Nutrition BioTech material, and no health, therapeutic or cosmetic outcome is claimed or implied for any finished product. Buyers are responsible for the claims they make on their own labels and for confirming what is permitted in their market.
- Biopharmaceutics classification and rat intestinal permeabilityReported equilibrium solubility in phosphate buffers with a maximum of 2.16 µg/mL at pH 7.5 and an intrinsic dissolution rate of 0.006 mg/min/cm². Effective permeability determined by single-pass intestinal perfusion in rats ranged from 0.198 × 10⁻⁴ cm/s at the jejunum to 0.713 × 10⁻⁴ cm/s at the duodenum. Relevant to solvent selection and dissolution testing.Zhang J, Liu D, Huang Y, Gao Y, Qian S. International Journal of Pharmaceutics. 2012;436(1–2):311–317. PMID 22796171 — source
- Solubility in twelve neat solvents and solid-state characterisationMeasured mole-fraction solubility at 298.2–318.2 K by a static equilibrium method with UPLC detection at 336 nm. Solubility was highest in PEG-400 (4.27 × 10⁻¹) and lowest in water (3.08 × 10⁻⁶) at 318.2 K. DSC gave a fusion temperature of 639.72 K and a fusion enthalpy of 49.66 kJ/mol, and the apparent thermodynamic analysis described dissolution as endothermic and entropy-driven in every solvent evaluated.Shakeel F, Alshehri S, Ibrahim MA, Elzayat EM, Altamimi MA, Mohsin K, Alanazi FK, Alsarra IA. Journal of Molecular Liquids. 2017;234:73–80. DOI 10.1016/j.molliq.2017.03.057 — source
- Solubility in ethanol–water mixturesMeasured solubility in ethanol + water mixtures by HPLC from 273.2 K to 323.2 K and reported that solubility increased with temperature and passed through a maximum at an intermediate ethanol/water composition rather than in either pure solvent.Xiao M, Yan W, Zhang Z. Journal of Chemical & Engineering Data. 2010;55:3346–3348. DOI 10.1021/je1001208 — source
Specification FAQ
What is the CAS number for Apigenin?
The CAS number for Apigenin is 520-36-5. The molecular formula is C15H10O5 and the molecular weight is 270.24 g/mol. Machine-readable identifiers: InChIKey KZNIFHPLKGYRTM-UHFFFAOYSA-N · PubChem CID 5280443.
What purity is Apigenin supplied at, and by which method?
98% minimum by HPLC, stated on the Certificate of Analysis for each lot.
Is Apigenin soluble in water?
Practically insoluble in water; soluble in DMSO and in dilute alkali. Particle size and wetting behaviour should be confirmed for the intended dosage form.
How is Apigenin produced and where does it come from?
Botanical extraction and purification (flavone naturally present in chamomile, parsley and celery). The plant source and solvent system for the supplied lot are stated on the specification sheet.
