NMN and NAD+ ingredient supplier specification
Nutrition BioTech is a bulk NAD+ precursor ingredient supplier and manufacturer, supplying NMN (beta-nicotinamide mononucleotide) at 99% minimum by HPLC (CAS 1094-61-7), alongside NAD+, NADH and liposomal NAD grades, for B2B nutraceutical and longevity-category formulation.
Every lot ships with a Certificate of Analysis stating identity, HPLC assay and the assay basis, from an ISO 22000 and FSSC 22000 certified quality system. Samples, specifications and COAs are available on request for formulation trials.
| Ingredient name | NMN 99% (NADSpa™) — beta-nicotinamide mononucleotide |
|---|---|
| Related grades | NAD+ plus (NADFlux™), NADH, NAD Liposomal plus (NADvitalize™). CAS numbers and assay methods for these grades are stated on their individual specification sheets. |
| Delivery platform name | PHOSPHERA™ is the Nutrition BioTech brand name for our phospholipid / liposomal delivery platform route. Grade identity, assay basis and method remain stated on the corresponding specification sheet and COA. |
| Synonyms | NMN; beta-NMN; nicotinamide ribonucleotide; nicotinamide mononucleotide |
| CAS number | 1094-61-7 (beta-nicotinamide mononucleotide) |
| Machine-readable identifiers | InChIKey DAYLJWODMCOQEW-TURQNECASA-N · PubChem CID 14180 |
| Molecular formula | C11H15N2O8P |
| Molecular weight | 334.22 g/mol |
| Assay / purity | NMN 99% minimum by HPLC. Assay for the NAD+, NADH and liposomal grades is stated on the corresponding specification sheet; grade options available on request. |
| Production route | Manufactured material (non-botanical). The production route for each grade is stated on its specification sheet. |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water; hygroscopic. Moisture-protective packaging and handling guidance available on request. |
| Typical applications | Capsules, tablets, sublingual and stick-pack powders, and liposomal formats for B2B dietary-supplement programs. |
| Documentation | Download public specification sheet Public sheet prepared from the current product-page specification block; not a batch-specific Certificate of Analysis. Lot-specific COA and supporting records are available for qualified buyer review when appropriate. |
| Quality system | ISO 22000:2018, FSSC 22000 and HACCP based quality system, GMP-aligned manufacturing; certificates available on request. |
| Supplier | Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States |
β-Nicotinamide Mononucleotide Specification Limits And Analytical Methods
Every specification below is the limit carried on our published product specification sheet, with the analytical method stated for each item.
| Test item | Specification | Method |
|---|---|---|
| β-Nicotinamide mononucleotide (assay) | NLT 99.0% | HPLC |
| Purity | NLT 99.0% | HPLC |
| Character | White to off-white crystalline powder | Organoleptic |
| Moisture | NMT 1.0% | USP–NF <921> |
| Bulk density | 0.5–0.7 g/mL | USP–NF <616> |
| Particle size (40 mesh) | NLT 95.0% | USP–NF <786> |
| pH | 2.0–4.0 | USP–NF <791> |
| Solubility | Soluble in water | USP–NF <1236> |
| Lead | NMT 0.5 ppm | USP–NF <233> |
| Arsenic | NMT 0.5 ppm | USP–NF <233> |
| Mercury | NMT 0.1 ppm | USP–NF <233> |
| Cadmium | NMT 0.5 ppm | USP–NF <233> |
| Total aerobic bacterial count | NMT 1,000 cfu/g | USP–NF <61> |
| Yeast and mould | NMT 100 cfu/g | USP–NF <61> |
| E. coli | Absent | USP–NF <62> |
| Salmonella | Absent | USP–NF <62> |
- Shelf life: three years.
- The obsolete total heavy-metals chapter line from the source COA is intentionally not published; current elemental rows use USP–NF <233>.
Method and limit block for buyer QA review. Batch-specific results, lot numbers, production dates and expiry dates are not published here.
NMN 99% (NADSpa™), NAD+ plus (NADFlux™), NADH, NAD Liposomal plus (NADvitalize™)
NAD ingredient platform for brands developing cellular energy and premium healthy-aging products.
Why brands ask for it
Nutrition BioTech offers an NAD+ booster platform covering NMN 99%, NAD+, NADH, liposomal NAD and advanced NAD-support concepts. We help brands select the right form for finished products: fast-dissolving powder, capsule-grade material, liposomal delivery or multi-ingredient NAD stacks.
Finished-product fit
Energy, healthy aging, NAD+ support, mitochondrial support, fast-dissolve and advanced delivery formats. The strongest conversations start with format, serving size, documentation, and how the material behaves in the intended formula.
What makes the sample useful
- Platform not single commodity
- Fast dissolve vs high bulk density/capsule grade
- Liposomal/enteric/NAD stack differentiation
Before the sample ships
- Confirm dissolution, dispersion, and the intended powder or granule format.
- Confirm powder or granule.
- Confirm active marker, assay method, and specification range.
- Review stability expectations and storage conditions for the finished format.
- Confirm the regulatory review route for the intended market.
File Package
Ask for the material files that match your market, dosage form, and internal review process.
Available documents may include: COA / Specification / Allergen Statement / GMO Statement / Vegan Statement / Heavy Metals / Microbial Limits / Manufacturing Flow Chart / Residual Solvent / Country of Origin / Composition Statement.
Regulatory & Facility Support
Regulatory review notes for the target market can be provided. Nutrition BioTech does not hold and does not claim any GRAS notification or NDI notification for this material.
Facility and quality system support follows the same certificate set named in the specification table: ISO 22000:2018, FSSC 22000, HACCP and GMP. The holding entity for each certificate is named on the certificate and confirmed under buyer review.
Regulatory status of NMN in the United States
The entries below summarise publicly available FDA correspondence and are provided as regulatory context for buyers. They are not claims about Nutrition BioTech material, and no health outcome is claimed or implied for any finished product. Buyers are responsible for confirming the status of the ingredient in their own market and for the claims they make on their own labels. Last reviewed: 3 August 2026.
FDA set aside its exclusion of NMN from the dietary supplement definition
FDA reconsidered and changed its interpretation of one aspect of 21 U.S.C. § 321(ff)(3)(B) and determined that NMN is not excluded from the dietary supplement definition, in its response to an amended citizen petition from the Natural Products Association and the Alliance for Natural Health USA. The petition was received on 6 March 2023.
FDA response to citizen petition, 29 September 2025. Docket FDA-2023-P-0872-2754 — source
Earlier notification responses reinstated on 2 December 2025
FDA set aside its 4 November 2022 superseding letters and reinstated its earlier responses to the NMN new dietary ingredient notifications, in letters issued to the notifiers by the Chief of the Identity and Status Branch, Office of Dietary Supplement Programs.
FDA letters dated 2 December 2025, Docket FDA-2022-S-0023 — source
New dietary ingredient notifications for NMN on the public record
Five NMN notifications appear on the public record: NDIN 1189 and 1234 (Willy Chemicals / Willy Nutra, responses dated 11 February 2021 and 18 January 2022), NDIN 1240 and 1247 (SyncoZymes (Shanghai) Co., Ltd., responses dated 24 February 2022 and 16 May 2022) and NDIN 1259 (Inner Mongolia Kingdomway Pharmaceutical Limited). FDA acknowledged receipt and filing without objection for NDIN 1247; the responses to NDIN 1189, 1234 and 1240 were letters of acknowledgement and objections.
FDA letters dated 2 December 2025, Docket FDA-2022-S-0023 — source
Conditions of use stated in NDIN 1259
The amended notification underlying NDIN 1259 stated conditions of use of dietary supplements marketed to adults in tablet, capsule or powder form at levels not exceeding 400 mg NMN per serving or 400 mg NMN per day.
FDA letter to Inner Mongolia Kingdomway Pharmaceutical Limited, 2 December 2025 — source
What acknowledgement of a notification does and does not mean
FDA states that acceptance of a notification for filing is a procedural matter and does not constitute a finding by FDA that the new dietary ingredient, or a supplement containing it, is safe or is not adulterated. NMN remains a new dietary ingredient: a firm marketing it must be covered by a premarket notification under 21 U.S.C. § 350b unless the ingredient is sourced from a supplier whose notification already covers that use.
21 CFR 190.6(c); FDA letter dated 2 December 2025 — source
Referencing a supplier notification through a Master File
FDA issued draft guidance on New Dietary Ingredient Notification Master Files for Dietary Supplements on 4 April 2024, describing how a notification may reference a Master File held by an ingredient supplier. The draft guidance represents FDA current thinking and is not binding.
Draft Guidance for Industry, 4 April 2024. Docket FDA-2024-D-0706 — source
Specification FAQ
What is the CAS number for NMN?
The CAS number for NMN is 1094-61-7 (beta-nicotinamide mononucleotide). The molecular formula is C11H15N2O8P and the molecular weight is 334.22 g/mol. Machine-readable identifiers: InChIKey DAYLJWODMCOQEW-TURQNECASA-N · PubChem CID 14180.
What purity is NMN supplied at, and by which method?
NMN 99% minimum by HPLC. Assay for the NAD+, NADH and liposomal grades is stated on the corresponding specification sheet; grade options available on request.
Is NMN soluble in water?
Freely soluble in water; hygroscopic. Moisture-protective packaging and handling guidance available on request.
Published research context
Nicotinamide mononucleotide and NAD+ have a long peer-reviewed literature. The studies below are provided as technical context for formulators evaluating this raw material. These entries summarise what the cited publications report. They are not claims about Nutrition BioTech material, and no health, therapeutic or cosmetic outcome is claimed or implied for any finished product. Buyers are responsible for the claims they make on their own labels and for confirming what is permitted in their market.
- Degradation kinetics in aqueous solution and the HPLC method used to follow itReported that degradation of NMN in aqueous solution followed apparent first-order kinetics, with the rate governed mainly by temperature and pH. NMN was reported to be more stable at low temperature and in neutral or weakly acidic conditions, while strong acid or strong alkali accelerated degradation, and the degradation rate was reported to be less affected by pepsin and trypsin. At room temperature in aqueous solution the authors reported a t0.9 of 95.58 h and a t1/2 of 860.26 h. Separation used a C18 column with methanol and 10 mmol/L ammonium formate gradient elution, detection at 266 nm, column temperature 30 degrees Celsius and a flow rate of 1.0 mL/min.Xiang DH, Feng WH, Yi H, Li C. Zhongguo Zhong Yao Za Zhi. 2023;48(24):6635-6644. PMID 38212023. DOI 10.19540/j.cnki.cjcmm.20230905.301. source
- Related-substances method and forced degradation for enzymatically produced NMNDeveloped an HPLC method for NMN and its potential impurities arising from nicotinamide riboside kinase production and from storage. Forced degradation was carried out under acid, base, oxidative, photolytic and thermal conditions. Separation was achieved on an ODS column using a phosphate buffer and methanol gradient at 1.0 mL/min with detection at 260 nm, resolution between all related substances was better than 1.5, and significant degradation was observed under basic and thermal conditions.Zhou H, Liu A, Hu M, Zheng X. J Chromatogr Sci. 2024;62(3):241-248. PMID 36617938. DOI 10.1093/chromsci/bmac107. source
- Buffer choice and temperature in long-term storage of NAD+ and NADHMeasured NAD+ and NADH stability in sodium phosphate, HEPES and Tris buffers at 19 and 25 degrees Celsius for up to 43 days. In Tris both were reported to be highly stable, with NADH degradation rates of 4 uM per day at 19 degrees Celsius and 11 uM per day at 25 degrees Celsius, corresponding to more than 90 percent and about 75 percent remaining after 43 days. Higher degradation rates, up to 34 uM per day, were reported in sodium phosphate or HEPES, and degradation was monitored by UV-Vis.Wolfe KD, Alahuhta M, Himmel ME, Bomble YJ. Molecules. 2024;29(22):5453. PMID 39598842. DOI 10.3390/molecules29225453. source
