Views: 1000 Author: Site Editor Publish Time: 2025-11-10 Origin: Site
Against the backdrop of the increasingly prominent global aging issue, Japan, as an "unprecedentedly long-lived country", has long been at the forefront of the world in the field of anti-aging care. Its concept of anti-aging is not only limited to "delaying aging" but has also been upgraded to the dual pursuit of "physical rejuvenation" and "spending years in good health". Today, from the three core directions of anti-glycation, anti-oxidation, and anti-inflammation, to Senolytics technology, epigenetics research, and the development of popular exosomes, Japan's anti-aging care is setting a benchmark for the global health industry with a diversified and scientific approach.
The "Japan Health Industry Exhibition" held at Tokyo Big Sight from June 27 to 29 this year further demonstrated Japan's leading strength in this field in an intuitive way. In the "Anti-Aging Japan" exhibition area of the event, the world's first orally stable glutathione raw material made a stunning debut. Professor Akira Kubo, a medical doctor from the International University of Health and Welfare, also gave an on-site speech on cutting-edge research, attracting global attention. All these facts confirm that Japan has reached world-class standards in the technological research and development, raw material innovation, and dissemination of health concepts in the field of anti-aging care.
Epigenetics is a branch of biology that studies the mechanism by which gene functions change due to factors such as aging and lifestyle without altering the DNA sequence itself. It tells us that human aging is not entirely determined by genetics; acquired factors such as the external environment and lifestyle also affect gene functions, thereby influencing a person's biological age. Recent studies have clearly confirmed the correlation between biological age, physical functions, and mortality risk, proving that these indicators can serve as effective markers for measuring health and longevity. In the field of health food, many enterprises are also committed to developing scientifically sound health methods by leveraging relevant research results. For example, DSM conducted a 3-year human clinical trial and confirmed that the combination of Omega-3 fatty acids and vitamin B can inhibit cognitive decline, and has promoted these results to the medical field. Yamato Pharmaceutical also published research showing that its product "Biobran (rice bran arabinoxylan derivative)" can enhance the effect of Senolytics and improve epigenetic indicators, providing a new technical direction for the industry.
The in-depth logic of Japan's anti-aging care has always revolved around the three directions of anti-glycation, anti-oxidation, and anti-inflammation, and in recent years, there have been continuous advancements in technology and application.
With the increase in age and exposure to ultraviolet rays, a large amount of "reactive oxygen species" are produced in the body. These substances not only accelerate aging but also weaken the immune function. To combat oxidation, Japan has continuously made efforts in the research and development of antioxidant ingredients. In addition to common vitamins, plant chemical components such as glutathione, carotenoids, and polyphenols have shown outstanding performance. Reports indicate that their antioxidant capacity is far higher than that of vitamin C and vitamin E, making them core raw materials in health foods and cosmetics.
"Glycation reaction" is another major culprit of aging. When proteins in the body combine with excess sugars, a type of aging substance called "AGEs (advanced glycation end products)" is produced. AGEs not only cause wrinkles, sagging, and dullness of the skin but also trigger various diseases such as arteriosclerosis. In response to the demand for anti-glycation, Japanese enterprises have developed a variety of raw materials and products that can inhibit the formation of AGEs, reducing the accumulation of aging substances at the source.
On one hand, "Sirtuin (longevity gene)" has become a research hotspot, as it has been proven to inhibit the root cause of inflammation. On the other hand, "spermidine" and other polyamine substances rich in fermented foods have become new favorites in anti-aging ingredients in recent years due to their effects of anti-inflammation and delaying cell aging, and are widely used in the field of health foods.
In Japan's anti-aging care market, women aged 40 to 50 are the core consumer group. Traditional ingredients such as collagen, hyaluronic acid, placenta extract, and vitamins are still popular. However, in recent years, the rise of exosome and Senolytics technologies is reshaping the market pattern.
Exosomes, which have the functions of repairing cells and delivering active substances, first gained popularity in the cosmetics field. Now, the food industry is also accelerating its layout. Although the price of exosome raw materials is still relatively high, the orders for customized products containing exosomes plus ingredients such as collagen, hyaluronic acid, etc., are booming. At the same time, the demand for plant-derived exosome supplements has been increasing year by year. At cosmetic raw material exhibitions, exosome raw materials have become the "stars". For example, yeast-derived exosomes capable of producing NMN have become popular raw materials in the industry due to their effects in hair growth, beauty, and anti-aging (with 14 related papers published).
In March this year, Fancl launched a supplement containing "Akebia stem extract" called "Kimizuhime Yurai Ageless Well", which claims to reduce the accumulation of senescent cells;
Wakamoto Pharmaceutical developed a Jerusalem artichoke-derived raw material "Wakamoto SenoClear" and confirmed its effect of eliminating senescent cells. It has been adopted by comprehensive mail-order sales companies, and the order performance of related products is good;
Glico has also applied for a patent for the use of quercetin as a senescent cell scavenger, and it is expected that the application of this ingredient in health foods or supplements will accelerate in the future.
The core active ingredients of Senolytics include quercetin, NMN, etc. It is worth noting that quercetin itself is not a scavenger; it needs to be converted into a substance capable of eliminating senescent cells and repairing damaged cells under the action of an enzyme in the body. In addition, ingredients such as PQQ, 5-ALA, and hydrogen are related to the production of ATP (energy) in mitochondria. Therefore, it is expected that the combination of these ingredients with NMN will produce a synergistic effect, which has become a new direction for enterprise research and development.
For suppliers, keeping up with the technological trends and market demands of Japan's anti-aging care will bring broad development space, whether it is deploying raw materials related to exosomes and Senolytics, or deepening the research on anti-glycation, anti-oxidation, and anti-inflammation ingredients. In the future, with the further maturity of technology and the upgrading of consumer demand, Japan's anti-aging care will surely continue to lead the global trend and contribute more to the cause of healthy longevity.
Important Reminder：All content in this article is for general reference only and is provided solely to offer information support for practitioners in the nutrition and health industry. Descriptions related to efficacy are supported by corresponding data, but they do not represent claims or guidance for consumers. Content related to health, medical care, and technological applications is for reference only. For medical matters, please consult professional medical institutions and follow medical advice. This article does not provide any medical recommendations.
