Dihydroberberine (DHB) supplier specification
Nutrition BioTech is a bulk dihydroberberine ingredient supplier and manufacturer, supplying DHB powder at 98% minimum by HPLC (CAS 483-15-8), produced by controlled reduction of berberine, for B2B nutraceutical and dietary-supplement formulation.
Every lot ships with a Certificate of Analysis stating identity, HPLC assay and the assay basis, from an ISO 22000 and FSSC 22000 certified quality system. Samples, specifications and COAs are available on request for formulation trials.
| Ingredient name | Dihydroberberine (DHB) |
|---|---|
| Synonyms | DHB; 7,8-dihydroberberine; reduced berberine; protoberberine-class isoquinoline alkaloid |
| CAS number | 483-15-8 |
| Molecular formula | C20H19NO4 |
| Molecular weight | 337.37 g/mol |
| Assay / purity | 98% minimum by HPLC; other grades available on request. |
| Production route | Controlled reduction of berberine (itself obtained from Phellodendron and Coptis botanical sources). Route and starting material are stated in the lot documentation. |
| Appearance | Yellow to yellow-brown crystalline powder |
| Solubility | Practically insoluble in water; soluble in methanol, ethanol and DMSO. DHB is oxidation-sensitive; protective packaging and handling guidance are supplied with the specification. |
| Typical applications | Capsules, tablets and low-dose powder blends for B2B dietary-supplement programs; stability-focused formats reviewed per project. |
| Documentation | Certificate of Analysis (identity and HPLC assay with assay basis), specification sheet, heavy metals, microbiological, residual solvents, allergen and GMO statements; stability data available on request. |
| Quality system | ISO 22000:2018, FSSC 22000 and HACCP based quality system, GMP-aligned manufacturing; certificates available on request. |
| Supplier | Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States |
DHB Pro-Stable / stability-first product route
DHB Pro-Stable: the berberine upgrade has to survive the launch path.
Dihydroberberine can give metabolic-wellness brands a premium upgrade story, but the buyer review should not stop at a single headline. The real launch questions are stability, bitterness, color, packaging, sensory direction and technical file readiness.
Buyer reframe
Getting attention is easy. Passing formulation review is harder.
Many DHB products compete on headline bioavailability. A serious B2B launch has to go further: how the material behaves in sachets, powders, capsules or chewables; whether bitterness and color can be managed; what packaging route is realistic; and which files R&D, QA and regulatory teams need before launch planning.
Stability
Review the intended format, storage condition, water activity direction and packaging assumptions before choosing the finished-product route.
retention reviewpackaging
Taste and color
Bitterness, yellowing, appearance and sensory direction matter early, especially for powders, sachets, gummies and chewables.
bitternesscolor drift
File readiness
DHB should move with a clear technical review path: COA/spec, assay, safety files, allergen/GMO/vegan statements as applicable, and launch-language support.
COA/specclaim boundary
Best-fit applications
Where DHB Pro-Stable fits
- Post-GLP-1 companion sachets paired with protein, fiber, creatine or gut-metabolic support ingredients.
- Premium berberine-family upgrade concepts where the brand needs a sharper technical reason to exist.
- Powder and stick-pack formats where stability, bitterness, color and packaging need early review.
- Capsule or tablet lines where DHB is used as the technical upgrade while Berberine Pro-Micelle supports the broader platform story.
DHB launch review checklist
What a serious buyer should review before choosing a DHB route
Material identity
- DHB assay and specification.
- Source identity and production route discussion where available.
- COA and method notes for buyer review.
Format risk
- Stability discussion for the target dosage form.
- Bitterness, appearance and color notes.
- Packaging recommendation for the intended route.
Commercial readiness
- Sample and application review route.
- QA / regulatory file package as applicable.
- Supplement-category launch wording and claim-boundary support.
Connected route
Use DHB Pro-Stable as the technical upgrade, then build the platform around the formula job.
DHB Pro-Stable is strongest when the buyer needs a premium berberine-family route with stability, taste, color, packaging and file review. Berberine Pro-Micelle can carry the broader routine-fit and dispersion discussion.
Together, they give Post-GLP-1 companion concepts a product-first architecture: material selection first, platform logic second, application and file package third.
FAQ for brand teams
DHB Pro-Stable FAQ
Is DHB only an absorption story?
No. For a serious product launch, the better question is whether the ingredient route can support the target format, taste, color, packaging, file package and supplement-category language.
Which formats should be reviewed first?
Capsules and tablets are the simpler starting point. Sachets, powders, gummies and chewables need earlier review of bitterness, color, water exposure, processing route and packaging direction.
What should a buyer request first?
Ask for sample availability, COA/spec, assay method, stability discussion for the intended format, sensory direction, packaging recommendation and file-package support.
Do not launch DHB on a headline alone.
Nutrition BioTech can review DHB Pro-Stable against the target format, stability route, sensory direction, sample path, file package and public claim boundary before your brand commits to a formula.
Related ingredient pages
For buyer evaluation, compare this guide with the closest Nutrition BioTech ingredient pages and sourcing route.
