Fisetin Manufacturer and Supplier Guide: Sourcing Standardised Fisetin

Fisetin supplier specification

Nutrition BioTech is a bulk fisetin ingredient supplier and manufacturer, supplying standardised fisetin powder at 98% purity by HPLC, extracted from Rhus succedanea, for B2B nutraceutical and cosmetic formulation. Material ships with a Certificate of Analysis stating identity, HPLC assay and the assay basis, from an ISO 22000 and FSSC 22000 certified quality system. Samples, specifications and COAs are available on request for formulation trials.

Ingredient name	Fisetin
Synonyms	3,3′,4′,7-tetrahydroxyflavone; fisetol
CAS number	528-48-3
Molecular formula	C₁₅H₁₀O₆
Molecular weight	286.24 g/mol
Assay / purity	98% minimum by HPLC; lower-percentage standardised extracts available on request
Botanical source	Rhus succedanea (wax tree); Cotinus coggygria material also available in the wider market
Appearance	Yellow to mustard-yellow fine powder
Solubility	Practically insoluble in water; soluble in DMSO and ethanol
Typical applications	Capsules, tablets, powder blends and low-dose longevity-category formulations; topical and cosmetic formulation on request
Documentation	COA, specification sheet, heavy metals, microbiology, residual solvents, pesticide screening, allergen and GMO statements, stability data
Quality system	ISO 22000:2018, FSSC 22000, HACCP, GMP; certificates available on request
Supplier	Nutrition BioTech, 1601 W. Mission Blvd, Suite 103 (DL#29), Pomona, CA 91766, United States

Short answer

Choosing a fisetin manufacturer comes down to four things: the botanical source, whether you are buying a purified compound or a standardised extract, whether the assay is backed by a real HPLC method and reference standard, and whether the supplier can document the material at the level your QA team will actually ask for. Commercial fisetin is produced from a small number of botanical sources — most often Rhus succedanea (wax tree) and Cotinus coggygria (smoke tree) — and is sold anywhere from low-percentage extracts to purified 98%+ material. Those are not the same product, and quotes across them are not comparable. Nutrition BioTech supplies standardised fisetin for B2B formulation with the documentation set below.

The four questions that decide a fisetin supplier

1. What is the botanical source, and does the spec say so?

The two sources you will encounter most often in the market are Rhus succedanea and Cotinus coggygria. Both are legitimate commercial routes to fisetin. What matters for your file is not which one is “better” in the abstract, but that the source and plant part are stated on the specification, are consistent lot to lot, and match what your label and your customer-service team will say. A supplier who cannot name the source and part used on paper is a supplier your QA team will have to chase later.

2. Purified compound or standardised extract?

This is where most price comparisons go wrong. A “fisetin 98%” purified material and a “fisetin extract standardised to 20%” are different products at different price points serving different formulas. Before comparing two numbers, confirm:

Is the percentage purity of a purified compound, or standardisation of an extract?
What is the balance of the material in an extract — other flavonoids, plant matrix, carriers?
Is the figure on a dried basis, and is moisture stated separately?

3. Does the assay stand up?

Ask for the method, not just the number:

HPLC assay with the method summary, and the reference standard it was run against.
Identity confirmation in addition to assay — assay alone tells you how much, not what.
Which related flavonoids the method resolves. Fisetin sits in a family of structurally close flavonols, and a method that does not separate them can flatter a result.
Lot-to-lot assay data, not a single flattering certificate.

4. Can they document it to QA standard?

The gap between a trading company and a manufacturer shows up here faster than anywhere else. See the checklist below.

Fisetin material properties that decide your format

Property	What to expect	Why it matters in the formula
Appearance	Yellow to mustard-yellow powder	Colour carries through into gummies, powders and tablets — plan the base colour around it
Water solubility	Practically insoluble	Will not simply dissolve in a water-based system; dispersion approach matters more than assay
Typical inclusion	Low milligram range per serving	Low-dose active: blend uniformity and segregation are the real risks, not fill volume
Particle size / bulk density	Request on spec	Predicts blending, filling and segregation behaviour better than the assay figure does
Format fit	Capsules and tablets are straightforward; beverages, sticks and gummies need a dispersion strategy	Decide the format before you specify the grade, not after
Delivery options	Ask about solubility-improved and dispersible formats	Only worth paying for if your format actually needs it

Documentation checklist — what to request before you sample

COA with identity, HPLC assay, method reference and the basis of the figure.
Specification sheet naming the botanical source and plant part, and the grade.
Heavy metals, microbiology, residual solvents and pesticide screening.
Allergen and GMO statements.
Particle size, bulk density and moisture.
Stability data in a format close to yours, with finished-unit assay where available.
Manufacturing site and quality-system certifications, with honest attribution of who holds what.
Regulatory position for your market, confirmed by your own regulatory team. Do not assume another supplier’s regulatory work covers a different supplier’s material — safety determinations and notifications are specific to a material, a producer and a specification, and they do not transfer with a purchase order.

For how to read these files critically, see how to verify a supplier COA and how to qualify a nutraceutical ingredient supplier. Our quality system and available certificates are on the Quality & Certifications page.

Red flags when sourcing fisetin

An assay percentage with no method and no reference standard behind it.
A specification that does not name the botanical source or plant part.
Purity and standardisation used interchangeably in the same quote.
Health-outcome language in supplier marketing. If a supplier is making efficacy claims to you, they are also making them to your competitors’ regulatory departments — and it tells you nothing about the material.
No stability data in anything resembling your finished format.

What we do not claim

This page covers sourcing, analytical identity and formulation properties only. We do not state or imply that fisetin treats, prevents, cures or diagnoses any disease, and we make no senolytic, anti-ageing, cognitive or immune-outcome claim. Finished-product claim language is the brand’s responsibility under DSHEA and should stay structure/function. Where we supply data, it is labelled by evidence stage — internal pilot, third-party tested, or report available under buyer review.

Related guides

Frequently asked questions

What should a fisetin specification state?

At minimum: the botanical source and plant part, whether the material is a purified compound or a standardised extract, the assay figure with the HPLC method and reference standard behind it, moisture and the basis of the assay, plus contaminant screening. A specification that omits the source or the method is not a specification you can qualify against.

What is the difference between fisetin 98% and a standardised fisetin extract?

A 98% material is a purified compound; a standardised extract contains fisetin at a stated percentage within a plant matrix. They serve different formulas and different price points, and comparing their percentages directly is misleading. Confirm which you are being quoted before you compare cost.

Which botanical sources is commercial fisetin produced from?

The two most common commercial routes are Rhus succedanea, the wax tree, and Cotinus coggygria, the smoke tree. Both are established sources. What matters for your file is that the source and plant part are stated on the specification and are consistent lot to lot.

Why does fisetin cost more than quercetin?

Quercetin is produced at commodity scale with a deep, competitive supply chain. Fisetin is a lower-volume specialty flavonol, so cost per gram is substantially higher. The practical offset is that fisetin is typically used at a much lower inclusion level, so compare cost per serving rather than cost per kilogram.

Is fisetin difficult to formulate?

It is practically insoluble in water and strongly coloured, so beverages, sticks and gummies need a dispersion strategy and a colour plan from the first bench trial. Because it is used at a low milligram level, blend uniformity is a bigger risk than fill volume. Capsules and tablets are the most straightforward route.

Does Nutrition BioTech supply fisetin?

Yes. Nutrition BioTech supplies standardised fisetin for B2B formulation, with COA, specification, method detail, application support and samples for formulation trials. Tell us your target grade, format, inclusion level and market and we will send the matching specification, COA and sample.

Request a fisetin sample, COA or spec

Tell us the grade you are evaluating, your target format and inclusion level, and your market, and we will return the matching specification, COA and a sample for your formulation trial — usually within one business day. Request a sample, COA or spec →