Liposomal PEA
What is PEA?
Palmitoylethanolamide (PEA) is an endogenous lipid modulator in animals and humans . It is found naturally in foods such as egg yolks and peanuts . It has been evaluated since the 1970s as an anti-inflammatory and analgesic drug in more than 30 clinical trials, in a total of ~6,000 patients. PEA is currently available worldwide as a nutraceutical in different formulations, with and without excipients.
The role of PEA in Human Body
PEA is a fatty acid amide molecule involved in a variety of cellular functions in chronic pain and inflammation. It has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (antipain) and anti-convulsant properties. Often in people with chronic disorders, the body does not produce enough PEA, which causes problems.
Why Liposomal PEA
For overcoming PEA¡¯s poor oral bioavailability, this is an ingredients consists of encapsulating PEA in a liposome. This liposome is composed of the same lipid material as the membrane of our cells. This means that it is completely tolerated by our body, while at the same time it enhance the bioavailability.
TEM Image: Liposomal PEA
PEA liposome was dissolved in H2O and the supernatant was used for TEM observation. The morphology of the prepared PEA liposome was characterized by a JEM-2100 transmission electron microscope (JEOL, Japan). The transmission electron microscopy (TEM) image shows that PEA liposome displays a uniform spherical morphology with an average diameter of 68.3 ¡À 19.7 nm.
